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SUMMARY:All Good Things Must Bend: the Energetics of DNA Shape and Flexibi
 lity in Biological Assemblies - Levene\, S (University of Texas at Dallas\
 , USA)
DTSTART:20120903T131000Z
DTEND:20120903T135000Z
UID:TALK39493@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:DNA-loop formation is an essential mechanistic aspect of many 
 biological processes including gene regulation\, DNA replication\, and rec
 ombination.  These loops are mediated by proteins bound at specific sites 
 along the contour of a single DNA molecule and are closely coupled to the 
 topological state of DNA domains through supercoiling\, knotting\, and lin
 king. The complex interplay between DNA topology and the regulation of DNA
  transactions remains poorly understood and the effects of a chromatin env
 ironment on such interactions are essentially unknown.  However\, new insi
 ghts can come from novel experimental approaches and computational models 
 of DNA flexibility and folding under geometric and/or topological constrai
 nts.  Experimental studies of Cre-loxP recombination and lac-repressor-med
 iated gene regulation will be used to illustrate the problems and general 
 principles of complex nucleoprotein organization.  A new method for direct
 ly computing the thermodynamic (i.e.\, free-energy) cost for mesoscopic mo
 dels of nucleoprotein assemblies will also be discussed.\n
LOCATION:Seminar Room 1\, Newton Institute
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