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SUMMARY:Dynamics of DNA supercoiling and knotting - Swigon\, D (University
  of Pittsburgh\, USA)
DTSTART:20120905T152000Z
DTEND:20120905T160000Z
UID:TALK39544@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Recent experiments on electrostatically induced migration of D
 NA in nanochanels reveal an intricate phenomenon of compaction of migratin
 g DNA that promotes knotting of the molecule. Subsequent relaxation of the
  molecule proceeds along several distinct kinetic regimes. The structural 
 details of DNA configurations in different stages of the process are yet u
 nknown. We investigate this and other related phenomena of DNA dynamics us
 ing a model in which DNA is represented by a charged elastic rod immersed 
 in a viscous incompressible fluid and the governing equations of the syste
 m are solved numerically using the generalized immersed boundary method. T
 he equations of motion of the rod include the fluidstructure interaction\,
  rod elasticity and a combination of two interactions that prevent self-co
 ntact\, namely the electrostatic interaction and hard-core repulsion. Pres
 ented will be results on the effects of electrostatics\, steric repulsion\
 , and thermal fluctuations on DNA supe rcoiling and knotting dynamics.\n\n
LOCATION:Seminar Room 1\, Newton Institute
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