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SUMMARY:Functionalized Antibodies - Professor Akira Harada\, Osaka Univers
 ity\, Japan
DTSTART:20121025T103000Z
DTEND:20121025T113000Z
UID:TALK39717@talks.cam.ac.uk
CONTACT:Sian Bunnage
DESCRIPTION:Monoclonal antibodies have been prepared against porphyrins\, 
 rhodium phosphine complexes\, and binaphthyl derivatives. The monoclonal a
 ntibody-porphyrin complex was found to catalyze some redox reactions as en
 zymes do. In addition\, the antibody for porphyrin-acceptor was found to b
 ind porphyrin and when the complex was irradiated by visible light in the 
 presence of viologen and hydrogenase or platinum colloid\, hydrogen gas wa
 s evolved from aqueous solution. The efficiency is the highest in the prot
 ein-porphyirin systems. The monoclonal antibody against rhodium phosphine 
 complex was found to bind the complex and the compound was found to cataly
 ze hydrogenation of amino acid precursors to give almost 100% L-amino acid
 \, although the rhodium phosphine complex is achiral.  This is due to the 
 second-sphere coordination effects. 
LOCATION:BP Institute
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