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SUMMARY:Toll and TLR function in inflammation and neurogenesis - Professor
  Nick Gay\, Department of Biochemistry\, Cambridge
DTSTART:20121107T123000Z
DTEND:20121107T133000Z
UID:TALK39766@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Although Drosophila Toll and vertebrate Toll-like receptors an
 d their signalling pathways have a common evolutionary origin\, the manner
  in which they recognise pathogen molecules is very different. The TLRs ar
 e bona fide pattern recognition receptors that directly bind a variety of 
 microbial molecules. On the other hand immunity is mediated almost exclusi
 vely in Drosophila by the Toll1 receptor\, which is activated by the endog
 enous cytokine Spatzle. What then is the function of the other 8 Drosophil
 a Toll receptors? Our recent studies in collaboration with Alicia Hidalgo 
 show that two of them Toll6 and 7\, act as neurotrophin receptors in the i
 nsect central nervous system. Mutants lacking Toll6/7 have profound behavi
 oural phenotypes and are activated by two Spatzle paralogues\, DNT1 and DN
 T2.\n \nI will also discuss recent results concerning the specificity and 
 regulation of the post receptor complexes\, in particular the nature of TI
 R-TIR interactions between receptors and adaptors and the role of phosphor
 ylation for the assembly and disassembly of Myddosomes.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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