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SUMMARY:Combinatorial and Dynamic Control Logic within pathogen-responsive
  Gene Regulatory Networks - Professor Alexander Hoffmann. University of Ca
 lifornia San Diego.  
DTSTART:20121115T160000Z
DTEND:20121115T170000Z
UID:TALK40253@talks.cam.ac.uk
CONTACT:Annabel Griffiths
DESCRIPTION:Studies of the cellular responses to pathogens have identified
  several primary response transcription factors (TFs)\, that are activated
  in stimulus-specific combinations and temporal profiles. To understand ho
 w dynamic activities may combine to produce the regulatory logic of pathog
 en-responsive gene expression\, we utilized mathematical modeling to guide
  the analysis of a multi-dimensional expression dataset of 714 transcripts
  induced by bacterial endotoxin. We found that gene clusters are controlle
 d by signal-responsive TFs either singly or sequentially in OR gates\, but
  that further specification of expression programs is mediated by constitu
 tive and signal-responsive mRNA halflife control. The results reveal that 
 mRNA halflife control is responsible for decoding not only stimulus-respon
 sive TF dynamics\, but also pathway combinatorics. We surmise that predict
 ive models of gene regulatory networks (GRNs) cannot be based on chromatin
 -associated events alone but must include non-nuclear control mechanisms a
 s well. Our work begins to delineate how intra-cellular combinatorial and 
 dynamic signals that encode information about the extra-cellular stimulus 
 are decoded through specific mechanisms within GRNs.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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