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SUMMARY:Cancer cell metabolism - basic biology and translational approache
 s - Ralph J. DeBerardinis\, University of Texas - Southwestern Medical Cen
 ter at Dallas
DTSTART:20130131T130000Z
DTEND:20130131T140000Z
UID:TALK40489@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Reprogramming metabolism is a hallmark of malignancy.  Underst
 anding the metabolic transitions that accompany transformation may produce
  translatable insights for cancer diagnosis and treatment.  We study tumor
  cell metabolism in culture\, mouse models\, and human patients.  By analy
 zing metabolism in cultured cells\, we have identified a finite set of cel
 l-autonomous metabolic platforms that support survival and growth.  These 
 platforms are easily distinguished from each other by analyzing the contri
 bution of glucose and glutamine to the tricarboxylic acid cycle.  We have 
 also developed methods to probe metabolism in models that more faithfully 
 recapitulate cell growth in vivo\, and to probe metabolism directly in liv
 e tumors.  This has revealed utilization of many of the same activities ob
 served in conventional culture\, as well as striking differences that pres
 umably reflect the effect of the microenvironment.  Ongoing work will deve
 lop methods to translate these findings into novel imaging approaches to d
 iagnose and monitor cancer.
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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