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SUMMARY:Cell specification in the mouse blastocyst inner cell mass: interp
 lay between Nanog\, Gata6 and the Fgf signalling pathway. - Dr Claire Chaz
 aud from Laboratoire GReD\, France 
DTSTART:20130131T143000Z
DTEND:20130131T153000Z
UID:TALK41987@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Our goal is to decipher the mechanisms of cell determination a
 nd differentiation in the preimplantation mouse embryo.  We are focusing o
 n Primitive Endoderm (PrE) versus Epiblast specification during blastocyst
  development and in the past years we have shown the interplay between dif
 ferent transcription factors such as Nanog for the Epiblast and Gata6\, So
 x17\, Gata4 and LRP2 for the PrE. We have recently shown that the Fgf4/RTK
  signalling plays several successive roles in inducing and maintaining PrE
  specification. These findings have an important impact in stem cell biolo
 gy\, as embryonic stem cells (ES) are derived from blastocysts. \n\n
LOCATION:Part II Room\, Department of Genetics
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