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SUMMARY:Molecular mechanisms that mediate the adaptation to hypoxia in Dro
 sophila. - Professor Pablo Wappner from Instituto Leloir\, Argentina 
DTSTART:20130307T143000Z
DTEND:20130307T153000Z
UID:TALK41992@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Adaptation to hypoxia involves a coordinated regulation of a w
 ide range of genes involved in restoring oxygen homeostasis. This response
  is mainly directed by the hypoxia-inducible factor (HIF) family of transc
 ription factors\, which are heterodimeric proteins consisting of two subun
 its: a HIF-α subunit that is tightly regulated by oxygen and a constituti
 ve HIF-β subunit. Oxygen negatively regulates HIF-α through proteasomal 
 degradation\, blockage of transcriptional co-activator recruitment and sub
 cellular localization. This hypoxia-responsive system is conserved in Dros
 ophila melanogaster\, being Sima and Tango the orthologues of HIF-α and H
 IF-β respectively. We have performed a genome-wide RNAi screen\, aimed to
  the identification of genes required for Sima activity in hypoxic conditi
 ons. We have found more than 20 novel regulators that are required for thi
 s response in vivo and characterized some of their mechanism of action. 
LOCATION:Part II Room\, Department of Genetics
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