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SUMMARY:Where Salt Goes Water Follows: Understanding Renal Salt Handling\,
  Blood Pressure and Thiazide Drugs - Keith Siew\, Clinical Pharmacology Un
 it\, ACCI\, Addenbrooke's Hospital
DTSTART:20130205T203000Z
DTEND:20130205T210000Z
UID:TALK42462@talks.cam.ac.uk
CONTACT:Roeland Verhallen
DESCRIPTION:Hypertension (high blood pressure) affects 1 in 4 over the age
  of 25 years\, contributing to an estimated 12.8% of global deaths. Despit
 e its prevalence and the abundance of research\, in approximately 95% of c
 ases the exact cause remains unknown.\n\nMy work aims to elucidate the reg
 ulatory mechanisms of salt handling by the kidney’s distal tubules and t
 he subsequent blood pressure changes due to water loss/retention. Of parti
 cular interest is the Na+-Cl- Cotransporter (NCC)\, the primary target of 
 anti-hypertensive thiazide diuretics\, often considered to be the first-li
 ne defence. Although NCC was once thought static and unchanging\, recent s
 tudies have revealed a complex and dynamic network of regulatory proteins 
 such as WNK\, SPAK\, and OSR1 controlling NCC activity. My talk will discu
 ss the newly discovered MO25α master regulator and its interactions with 
 the WNK-SPAK/OSR1-NCC signalling cascade\, some new insights into thiazide
  mechanisms of action\, as well as the potential for new and exciting ther
 apeutic targets.\n
LOCATION:Senior Parlour\, Gonville & Caius College
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