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SUMMARY:Evolution of post-translational networks - Dr. Pedro Beltrao\, EMB
 L-European Bioinformatics Institute
DTSTART:20130116T140000Z
DTEND:20130116T150000Z
UID:TALK42876@talks.cam.ac.uk
CONTACT:Danielle Stretch
DESCRIPTION:Cells have evolved intricate systems to sense changes in inter
 nal and external conditions. These changes are processed by the cell trigg
 ering an appropriate response most commonly via post-translational modific
 ations (PTMs) of proteins. However\, little is known about how these post-
 translational regulatory networks change during evolution. Recent advances
  in mass-spectrometry have allowed for the large-scale characterization of
  post-translational modifications in difference species opening the door f
 or comparative studies.\n\nI will review the progress that has been made i
 n understanding the evolutionary properties of post-translational regulati
 on and to place these advances in the context of the evolution of other ce
 llular interaction types. Novel types of PTMs (e.g. phosphorylation\, acet
 ylation\, ubiquitylation) arise rarely during evolution but can expand qui
 ckly once the available “writer”\, “reader” and “eraser” domai
 ns are available. Once in place\, PTM regulatory interactions can diverge 
 very rapidly with evolutionary properties analogous to transcriptional net
 works. I will review also the computational methods that have recently bee
 n developed to predict the functional relevance of large-scale sets of PTM
 s and consequences of their evolutionary changes.\n\n\nThe talk is part of
  the CCBI seminar series and the DTP graduate course Reviews in Computatio
 nal Biology\, but is open to all attendees.\n\n
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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