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SUMMARY:Deconstructing Metastasis - Epigenetic Expansion of the VHL-HIF Si
 gnal Output Drives Renal Cancer Progression - Dr Sakari Vanharanta\, Cance
 r Biology and Genetics Programme\, Memorial Sloan-Kettering Cancer Centre\
 , USA
DTSTART:20130301T143000Z
DTEND:20130301T153000Z
UID:TALK43126@talks.cam.ac.uk
CONTACT:Dr Ireena Dutta
DESCRIPTION:Clear cell renal cancer\, the most common form of kidney cance
 r\, is initiated by inactivating mutations in the VHL tumour suppressor ge
 ne. This leads to the activation of HIF transcription factors\, which is e
 ssential for renal cancer development\, but does not automatically lead to
  the metastatic spread of the tumour. New results show that in some patien
 ts\, epigenetic alterations can allow the expansion of the VHL-HIF transcr
 iptional output\, leading to the activation of metastatic traits.
LOCATION:Sackler Lecture Theatre\, CIMR\,  Level 7
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