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SUMMARY:Harnessing Genetic Dependencies in Cancer Therapy - Alan Ashworth\
 , The Institute of Cancer Research\, London
DTSTART:20131212T130000Z
DTEND:20131212T140000Z
UID:TALK43576@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:The design of targeted therapeutic strategies for cancer has l
 argely been driven by the identification of tumor-specific genetic changes
 . However\, the large number of genetic alterations present in tumor cells
  means that it is difficult to discriminate between genes that are critica
 l for maintaining the disease state and those that are merely coincidental
 . Even when critical genes can be identified\, directly targeting these is
  often challenging. We have exploited principles utilised for many years i
 n model organisms to address these issues. Here I will describe particular
  examples of the use of synthetic lethality in cancer therapy. In addition
 \, I will discuss high-throughput screening strategies to identify genetic
  dependencies in tumours.\n\n
LOCATION:Cancer Research UK Cambridge Institute\, Lecture Theatre
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