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SUMMARY:Tracking transmission and evolution of bacterial pathogens with hi
 gh-throughput genomics. - Dr Julian Parkhill\, Wellcome Trust Sanger Insti
 tute 
DTSTART:20130509T133000Z
DTEND:20130509T143000Z
UID:TALK44085@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:High-throughput sequencing technologies allow us to perform ra
 pid whole-genome sequencing for hundreds of bacterial strains simultaneous
 ly. Using these techniques\, we can perform genome sequencing at the popul
 ation level in order to identify genetic variation for epidemiology\, and 
 to look for the signatures of selective pressure and evolutionary change. 
 Data from population-level studies on human pathogens including Staphylocc
 us aureus\, Streptococcus pneumoniae and Vibrio cholerae will be presented
  showing how we can track transmission routes\, and identify the response 
 of these organisms to selective pressures such as antibiotics and vaccines
 . Advances in rapid sequencing will soon allow the use of these technologi
 es in clinical microbiology for tracking outbreaks and identifying drug re
 sistance\, and pilot studies demonstrating the power of these technologies
  will be presented.
LOCATION:Part II Room\, Department of Genetics
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