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SUMMARY:Feedback control of the anaphase-telophase transition. - Dr Helder
  Maiato\, Chromosome Instability & Dynamics Lab.\, Universidade do Porto 
DTSTART:20130613T133000Z
DTEND:20130613T143000Z
UID:TALK44086@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Faithful chromosome segregation during anaphase of mitosis req
 uires the physical and synchronous separation of two sets of sister-chroma
 tids that will give rise to genetically identical daughter cell nuclei. Cr
 itically\, nuclear envelope reassembly at telophase must therefore enclosu
 re each and entire set of sister-chromatids\, implying spatiotemporal coor
 dination with the mechanisms that govern anaphase. Using Drosophila melano
 gaster S2 cells has model system\, we identified a novel feedback control 
 mechanism that delays chromosome decondensation and nuclear envelope refor
 mation is response to slow spindle elongation during anaphase. We show tha
 t this mechanism is dependent on a gradient of Aurora B activity at the sp
 indle midzone. In this presentation I will present evidence in support of 
 a new mitotic checkpoint that prevents premature chromosome decondensation
  and nuclear envelope reassembly before effective separation of sister chr
 omatids is achieved. 
LOCATION:Part II Room\, Department of Genetics
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