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SUMMARY:The CLV/RPK2 pathway is necessary for the transition from two to t
 hree-dimensional growth in moss  - Joseph Cammarata
DTSTART:20130628T113000Z
DTEND:20130628T120000Z
UID:TALK44282@talks.cam.ac.uk
CONTACT:Megan Cooper
DESCRIPTION:The transition from colonizing two-dimensional space to growin
 g three-dimensional aerial shoots was an evolutionary step that allowed fo
 r the diversity of form and function seen in land plants today. The moss P
 hyscomitrella patens undergoes this same developmental switch as it transi
 tions from filamentous to leafy shoot growth. This change in growth is rep
 resentative of a change in the activity of stem cells\, and while this dec
 ision is well characterized developmentally\, its underlying genetic basis
  is unknown. In Arabidopsis thaliana\, the size and identity of the stem c
 ell population in the apical meristem is regulated by the CLV/RPK2 pathway
  which consists of the CLV3 CLE signaling peptide\, the CLE receptors CLV1
 \, CLV2\, and RPK2\, and the WUSCHEL-related homeobox (WOX) gene WUS. Homo
 logs of each member of this module - CLEs\, CLE-receptors\, and WOX genes 
 - are all found in Physcomitrella. Using a targeted knockout strategy\, I 
 have disrupted PpRPK2 function in physcomitrella. These plants are defecti
 ve in their ability to form leafy shoots\, but not filaments. This suggest
 s an ancestral role for the CLV/RPK2 signaling pathway in regulating the a
 bility of apical meristems to generate three-dimensional plant form. 
LOCATION:Biffen Lecture Theater\, Department of Genetics
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