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SUMMARY:Max Perutz Lecture: Five ways that viruses use to enter the animal
  cell  - Professor Ari Helenius\, ETH Zurich\, Switzerland
DTSTART:20130430T133000Z
DTEND:20130430T143000Z
UID:TALK44562@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:When viruses enter host cells most of them follow a stepwise p
 rogram that involves attachment\, activation of signaling pathways\, endoc
 ytosis\, penetration into the cytosol\, intracellular transport\, and fina
 lly uncoating of the viral genome. Since these steps depend on cellular fu
 nctions\, hundreds of cellular proteins inadvertently end up assisting the
  viruses. Using high-end light microscopy\, automated siRNA and drug scree
 ning as well as biochemical and biophysical approaches\, we have analyzed 
 the cell biology of entry of viruses from different families. We find five
  distinct routes with penetration occurring in the plasma membrane\, early
  endosomes\, maturing and late endosomes\, macropinosomes\, and the ER. I 
 will review the general concepts\, and describe in more detail the entry s
 trategies used by influenza A and vaccinia virus. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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