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SUMMARY:Influence of HLA-C expression level on HIV control - Dr Richard Ap
 ps\, National Cancer Institute\, NIH Fredericks\, USA
DTSTART:20130703T113000Z
DTEND:20130703T123000Z
UID:TALK45064@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:A variant upstream of human leukocyte antigen C (HLA-C) shows 
 the most significant genome-wide effect on HIV control in European America
 ns and is also associated with the level of HLA-C expression. \n\nWe chara
 cterized the differential cell surface expression levels of all common HLA
 -C allotypes and tested directly for effects of HLA-C expression on outcom
 es of HIV infection in 5243 individuals. Increasing HLA-C expression was a
 ssociated with protection against multiple outcomes independently of indiv
 idual HLA allelic effects in both African and European Americans\, regardl
 ess of their distinct HLA-C frequencies and linkage relationships with HLA
 -B and HLA-A. \n\nHigher HLA-C expression was correlated with increased li
 kelihood of cytotoxic T lymphocyte responses and frequency of viral escape
  mutation. In contrast\, high HLA-C expression had a deleterious effect in
  Crohn's disease\, suggesting a broader influence of HLA expression levels
  in human disease.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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