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SUMMARY:Fc Receptors: Critical regulators of antibody biology and therapy 
 - Prof. Mark Cragg  - Faculty of Medicine\, University of Southampton
DTSTART:20130627T123000Z
DTEND:20130627T133000Z
UID:TALK46018@talks.cam.ac.uk
CONTACT:Dr Tennie Videler
DESCRIPTION:Monoclonal antibodies (mAb) represent a growing class of 'bloc
 k-buster' cancer drugs\, led by established reagents such as rituximab\, t
 rastuzumab\, and bevacizumab. Despite such success\, we are only now start
 ing to understand how these drugs work and therefore how they can be augme
 nted for better efficacy.\nWe have understood for some time that Fc gamma 
 receptors (FcR) on effector cells are critical for the in-vivo efficacy of
  direct-targeting mAb. However\, recent data from our lab and others indic
 ates that the situation is more complex than first appreciated. In this ta
 lk\, data will be presented revealing novel ways in which the biology of F
 cR can regulate mAb activity with clear implications for subsequent design
  of future reagents. In particular the inhibitory FcR (CD32B) will be expl
 ored as a target for manipulating various forms of immunotherapy.\n\n
LOCATION:MPLT\, MRC-LMB\, Francis Crick Avenue\, Cambridge Biomedical Camp
 us\, CB2 0QH
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