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SUMMARY:How does the kinetochore orchestrate a functional checkpoint signa
 l? - Professor Jakob Nilsson from The Novo Nordisk Foundation Center for P
 rotein Research\, University of Copenhagen 
DTSTART:20131010T133000Z
DTEND:20131010T143000Z
UID:TALK47259@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:The proper segregation of sister chromatids during mitosis dep
 ends on the Spindle Assembly Checkpoint (SAC)\, which delays anaphase onse
 t until all kinetochores have attached to microtubules. The SAC inhibits t
 he APC/C-Cdc20 complex\, a large ubiquitin ligase required for anaphase on
 set\, by the direct binding of two SAC proteins Mad2 and BubR1 to Cdc20. C
 dc20 is only inhibited when incorrectly attached kinetochores are present 
 which correlates with the localization of SAC proteins to the kinetochore.
  The recruitment of SAC proteins to the kinetochore is believed to be impo
 rtant for generating a functional checkpoint signal but exactly how this i
 s achieved at the molecular levels is unclear. I will present our recent p
 rogress in understanding how the SAC proteins interact with the kinetochor
 e and how this contributes to generating a functional checkpoint signal.
LOCATION:Part II Room\, Department of Genetics
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