BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Design of multi-arm multi-stage trials - James Wason\, MRC Biostat
 istics
DTSTART:20131125T191500Z
DTEND:20131125T213000Z
UID:TALK47522@talks.cam.ac.uk
CONTACT:Peter Watson
DESCRIPTION:In many disease areas there are multiple experimental treatmen
 ts awaiting testing in clinical trials. Multi-arm trials provide large gai
 ns in efficiency over separate randomised trials of each treatment by usin
 g a shared control group. Further increases in efficiency can be obtained 
 by introducing interim analyses at which modifications can be made to the 
 proportion of patients allocated to each treatment. Such a design is calle
 d a multi-arm multi-stage (MAMS) trial.  In this talk I will discuss and c
 ompare three classes of MAMS designs that can be used to increase efficien
 cy and ethical properties of a multi-arm trial: group-sequential designs\,
  drop-the-loser designs and adaptive randomisation. I will also discuss so
 me statistical issues that are common to all three.
LOCATION:Department of Applied Mathematics and Theoretical Physics\, Unive
 rsity of Cambidge
END:VEVENT
END:VCALENDAR