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SUMMARY:Francis Crick Lecture 2014: Prions Causing Neurodegeneration: A Un
 ifying Etiology and the Quest for Therapeutics - Stanley Prusiner\, Univer
 sity of California San Francisco 
DTSTART:20140411T140000Z
DTEND:20140411T160000Z
UID:TALK49169@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Mounting evidence argues that prions feature in the pathogenes
 is of many\, if not all\, neurodegenerative diseases.  Such disorders incl
 ude Alzheimer’s\, Parkinson’s\, Lou Gehrig’s and Creutzfeldt-Jakob d
 iseases as well as the fronto-temporal dementias.  In each of these illnes
 ses\, aberrant forms of a particular protein accumulate as pathological de
 posits referred to as amyloid plaques\, neurofibrillary tangles\, Lewy bod
 ies\, as well as glial cytoplasmic and/or nuclear inclusions.  The heritab
 le forms of the neurodegenerative diseases are often caused by mutations i
 n the genes encoding the mutant\, prion proteins that accumulate in the CN
 S of patients with these fatal disorders.  The late onset of the inherited
  neurodegenerative diseases seems likely to be explained by the protein qu
 ality control systems being less efficient in older neurons and thus\, mor
 e permissive for prion accumulation.  To date\, there is not a single drug
  that halts or even slows one neurodegenerative disease.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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