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SUMMARY:Deconstructing Greatwall Kinase. - Dr Helfrid Hochegger\, Universi
 ty of Sussex 
DTSTART:20140130T143000Z
DTEND:20140130T153000Z
UID:TALK49222@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Greatwall is a novel mitotic kinase that plays a crucial role 
 in regulating the Cdk counteracting phosphatase PP2A/B55.  The precise fun
 ctions and regulation of Greatwall kinase itself remains to be explored. I
 n my seminar I will report on work in my laboratory on the phosphatases th
 at counteract Greatwall activation. I will also discuss recent efforts in 
 the lab to develop Greatwall as a target in cancer therapy and present unp
 ublished work on a collaboration with the Pearl lab to solve the structure
  of this kinase and develop an in vitro screen to identify small molecule 
 inhibitors of Greatwall.
LOCATION:Part II Room\, Department of Genetics
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