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SUMMARY:"From trials evaluating drugs to trials evaluating treatment algor
 ithms – Focus on the SHIVA trial" - Dr Christophe Le Tourneau\, Medical 
 Oncologist\, Head of the Phase I Program at the Institut Curie\, Paris\, F
 rance\,
DTSTART:20140513T110000Z
DTEND:20140513T120000Z
UID:TALK49446@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:In oncology\, genomics has practically entered the clinic with
  the emergence of molecularly targeted agents. Some of these drugs have be
 en approved with a companion diagnostic based on a specific genomic molecu
 lar alteration. However\, molecularly targeted agents have followed the sa
 me clinical development as chemotherapeutic agents and have been developed
  in selected tumor types and histologies. The occurrence of the same molec
 ular alteration across various tumor types is well described\, although th
 e incidence and functional impact may vary. The latter raises the question
  of whether treatment decision in the future should be entirely based on m
 olecular biology\, independently of tumor location and histology. This app
 roach can today be addressed in clinical trials\, since major advances in 
 high throughput technologies now make it possible to depict most druggable
  molecular alterations for an affordable cost in a time that is compatible
  with clinical practice. Studies using high throughput technologies have b
 een initiated with the aim of personalizing therapy in oncology. They incl
 ude two distinct types of clinical trials: 1) stratified clinical trials a
 ccording to either molecular alterations or tumor types that still evaluat
 e drug’s efficacy in well-defined patient populations\, and 2) algorithm
 -based trials evaluating treatment algorithm efficiency instead of drugs e
 fficacy. Multiple challenges are associated with these trials in personali
 zed medicine.
LOCATION:CRI Lecture Theatre\, Cambridge Research Institute
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