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SUMMARY:Identification of ADP-ribosyl cyclase in Arabidopsis thaliana - S 
 M Abdul-Awal
DTSTART:20140612T150000Z
DTEND:20140612T152500Z
UID:TALK51418@talks.cam.ac.uk
CONTACT:Megan Cooper
DESCRIPTION:In animals\, ADP-ribosyl cyclase (ADPR cyclase) is a multifunc
 tional enzyme that catalyses nicotinamide adenine dinucleotide (NAD) and n
 icotinamide adenine dinucleotide phosphate (NADP) into two important secon
 d messengers\, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucl
 eotide phosphate (NAADP)\, respectively. cADPR targets the ryanodine recep
 tor (RyR) present in the sarco/endoplasmic reticulum (SR/ER) and acts as a
  potent calcium mobiliser in the cell. cADPR elevates cytosolic free Ca2+ 
 [Ca2+]cyt in plants and plays a central role in signal transduction pathwa
 ys evoked by the drought and stress hormone\, abscisic acid (ABA). We foun
 d that cADPR-mediated [Ca2+]cyt forms an additional cytosolic loop of the 
 circadian clock in Arabidopsis. CIRCADIAN CLOCK ASSOCIATED1 (CCA1) acts as
  a repressor of ADPR cyclase activity and in the absence of PSEUDORESPONSE
  REGULATOR9 (PRR9)\, and PRR579 the activity of CCA1 is increased\, thereb
 y reducing the activity of ADPR cyclase in Arabidopsis\, consistent with t
 he circadian regulation of [Ca2+]cyt. \nI will be talking about how cADPR-
 mediated [Ca2+]cyt is incorporated into the circadian clock and some aspec
 ts of the purification process of ADPR cyclase. \n
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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