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SUMMARY:Werner Complexes: A New Class of Chiral Hydrogen Bond Donor Cataly
 sts for Enantioselective Organic Reactions" - Professor John Gladysz\, Tex
 as A&M
DTSTART:20140519T150000Z
DTEND:20140519T160000Z
UID:TALK52405@talks.cam.ac.uk
CONTACT:Sian Bunnage
DESCRIPTION:Salts of the chiral tris(ethylenediamine)-substituted octahedr
 al trication [Co(en)3]3+\, and related species\, have played important his
 torical roles in the development of inorganic chemistry and stereochemistr
 y.1\,2 As Werner described in 1912\, the two enantiomers\, commonly design
 ated Λ and Δ\, can be separated by crystallization of the diastereomeric
  tartrate salts.2b However\, despite the low cost and ready availability o
 f the building blocks\, there have been no applications in enantioselectiv
 e organic synthesis.\n \nWe have found that [Co(en)3]3+ and related cation
 s can be rendered soluble in organic solvents by using lipophilic anions s
 uch as "BArf–".3 Suitably functionalized derivatives act as highly enant
 ioselective catalysts for a variety of carbon-carbon bond forming reaction
 s. The mechanisms involve outer sphere activation of the electrophile by h
 ydrogen bonding to the NH moieties. Other types of metal-containing chiral
  hydrogen bond donors are also effective\, including a chelate of the CpRu
 L fragment.\n \n1 	Kauffman\, G. B. Coord. Chem. Rev. 1974\, 12\, 105-149.
 \n2 	Werner\, A. Chem. Ber. 1911\, 44\, 1887-1898 and 1912\, 45\, 121-130.
 \n3 	Ganzmann\, C.\; Gladysz\, J. A. Chem. Eur. J. 2008\, 14\, 5397-5400.\
 n4 	Ghosh\, S. K.\; Ojeda\, A. S.\; Guerrero-Leal\, J.\; Bhuvanesh\, N.\; 
 Gladysz\, J. A. Inorg. Chem. 2013\, 52\, 9369-9378.\n5 	Thomas\, C.\; Glad
 ysz\, J. A. ACS Catalysis 2014\, 5\, 1134-1138.\n
LOCATION:Wolfson Lecture Theatre\, Department of Chemistry
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