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SUMMARY:The proteome of native AMPA-receptors and its significance for exc
 itatory neurotransmission - Bernd Fakler\, University of Freiburg
DTSTART:20140530T093000Z
DTEND:20140530T103000Z
UID:TALK52719@talks.cam.ac.uk
CONTACT:Ingo Greger
DESCRIPTION:Fast excitatory neurotransmission in the brain is primarily dr
 iven by postsynaptic AMPA-type glutamate receptors (AMPARs). Activated upo
 n glutamate release from presynaptic boutons\, AMPARs provide the transien
 t excitatory postsynaptic currents (EPSCs) required for propagation of the
  electrical signal. Both efficacy and reliability of the signal propagatio
 n are related to the time course and amplitude of the EPSCs that are shape
 d by the gating kinetics of the AMPARs and thus depend on the molecular co
 mposition of the receptor channels.\nRecent comprehensive proteomic analys
 es that we performed on membrane fractions from whole rodent brain showed 
 that native AMPARs are macromolecular complexes of considerable diversity 
 assembled from a pool of more than 30 different protein constituents mostl
 y transmembrane or secreted proteins. I will discuss the significance of t
 he AMPAR proteome for signal transduction and its specificity in individua
 l excitatory synapses in the mammalian brain. \nhttp://www2.mrc-lmb.cam.ac
 .uk/news-and-events/scientific-seminars/
LOCATION:Klug Seminar Room\, Level 2 2A180\, MRC LMB
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