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SUMMARY:The Consequences of Whole Genome Duplications - Prof David Pellman
 \, Professor of Cell Biology\, Harvard Medical School
DTSTART:20140722T151500Z
DTEND:20140722T170000Z
UID:TALK52780@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Whole genome duplications occur frequently during evolution\, 
 development and disease.  The consequences of whole genome duplication are
  not well understood\, but it has been speculated that the extra chromosom
 e sets\,\nextra centrosomes\, and accompanying genomic instability might f
 acilitate evolutionary adaptation.  Our laboratory previously demonstrated
  that whole genome duplications triggered by cytokinesis failure could dri
 ve tumor development. Current estimates suggest that whole genome\nduplica
 tions occur in nearly 40% of human cancers at some point during tumor deve
 lopment. I will discuss recent work on the consequences of whole genome du
 plications in human somatic cells. First\, I will discuss a mutagenesis me
 chanism that can occur if an intact chromosome is\nmissegregated into abno
 rmal nuclear structures called micronuclei.  This results in extensive mut
 agenesis that is unusual because it is localized to one or a few chromosom
 es.  Second\, I will describe a new tumor\nsuppressor signaling pathway th
 at senses cytokinesis failure and prevents the proliferation of the result
 ing tetraploid cells.  
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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