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SUMMARY:Crick Lecture 2014: How Aneuploidy Drives Cancer - Stephen Elledge
 \, Gregor Mendel Professor of Genetics\, Department of Genetics\, Harvard 
 Medical School
DTSTART:20140919T151500Z
DTEND:20140919T170000Z
UID:TALK52783@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Aneuploidy has been recognized as a hallmark of cancer for ove
 r 100 years\, yet no general theory to explain the recurring patterns of a
 neuploidy in cancer has emerged. We developed Tumor Suppressor and Oncogen
 e (TUSON) Explorer\, a computational method that analyzes the patterns of 
 mutational signatures in tumors and predicts the likelihood that any indiv
 idual gene functions as a tumor suppressor (TSG) or oncogene (OG). By anal
 yzing >8200 tumor-normal pairs we provide statistical evidence suggesting 
 many more genes possess cancer driver properties than anticipated\, formin
 g a continuum of oncogenic potential. Integrating our driver predictions w
 ith information on somatic copy number alterations\, we find that the dist
 ribution and the potency of TSGs (STOP genes)\, OGs and essential genes (G
 O genes) on chromosomes can predict the complex patterns of aneuploidy and
  copy number variation characteristic of cancer genomes. We propose that t
 he cancer genome is shaped through a process of cumulative haploinsufficie
 ncy and triplosensitivity. We are now assessing how aneuploidy drives canc
 er and the potency with which it does so.  Ramifications of aneuploidy wil
 l be discussed.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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