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SUMMARY:Small RNA-directed pathways in plants - Professor Jim Carrington\,
  Oregon State University
DTSTART:20061109T160000Z
DTEND:20061109T170000Z
UID:TALK5287@talks.cam.ac.uk
CONTACT:3901
DESCRIPTION:Eukaryotes contain a diversified set of small RNA-guided pathw
 ays\nthat control genes\, repeated sequences and viruses at the\ntranscrip
 tional and posttranscriptional level.  These pathways form\nmicroRNAs and 
 siRNAs\, and are essential for multicellular\ndevelopment\, genome mainten
 ance and integrity\, rapid responses to\nbiotic and abiotic stress\, and d
 efense.  Genome-wide profiling and\nanalyses of small RNAs and transcripts
  was done for wild-type\nArabidopsis thaliana and silencing pathway mutant
 s with defects in\nthree RNA-DEPENDENT RNA POLYMERASE (RDR) and four DICER
 -LIKE (DCL)\ngenes.  Profiling involves direct analysis using a multiplexe
 d\,\nparallel sequencing strategy.  This revealed diverse populations of\n
 small RNAs that target specific classes of genetic elements.   The\nmost a
 bundant small RNA class is dependent on RDR2 and DCL3\, and\ntargets repet
 itive elements across the genome.  The presentation will\nfocus on functio
 nal diversification of small RNA pathways\, and how\nthese pathways may in
 fluence the shape of plant genomes.\n\nSee http://jcclab.science.oregonsta
 te.edu/ for recent publications.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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