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SUMMARY:Dissecting a protein-protein interaction in living cells - Profess
 or Ashok Venkitaraman\, MRC Hutchison Laboratory
DTSTART:20061117T100000Z
DTEND:20061117T103000Z
UID:TALK5312@talks.cam.ac.uk
CONTACT:Duncan Simpson
DESCRIPTION:Proteins that sense and repair lesions in DNA maintain the int
 egrity of the human genome during cell division\, preventing the genetic i
 nstability that initiates diseases like cancer. These molecules work in mu
 lti-protein assemblies whose dynamic formation and dispersal underlies the
  reactions that lead to DNA repair\, but how these protein-protein interac
 tions are regulated is not well understood. In this talk\, I will describe
  our work on the interaction between the breast cancer suppressor protein 
 BRCA2 and its partner\, the DNA repair enzyme RAD51. We have combined meth
 ods from genetics\, biochemistry and biophysics to describe how BRCA2 cont
 rols the availability and polymerization of RAD51 during the repair of dou
 ble-strand DNA breaks in dividing cells.
LOCATION:Kaetsu Centre\, New Hall
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