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SUMMARY:Plenary Lecture 11: Numerical simulation of endocytosis - Lowengru
 b\, J (University of California\, Irvine)
DTSTART:20140627T090000Z
DTEND:20140627T094500Z
UID:TALK53203@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Co-authors: Sebastian Aland (UC Irvine/TU Dresden)\, Jun Allar
 d (UC Irvine) \n\nMany cell processes involve the formation of membrane ve
 sicles from a larger membrane\, including endocytosis\, inter-organelle tr
 ansport and virus entry. These events are typically orchestrated by curvat
 ure-inducing molecules attached to the membrane\, such as clathrin and bar
 -domain proteins. Recent reports demonstrate that in some circumstances ve
 sicles can form de novo in a few milliseconds\, e.g.\, ultrafast endocytos
 is at the neurological synapse. Membrane dynamics at these scales (millise
 cond\, nanometer) are dominated by hydrodynamic interactions\, as the memb
 rane pushes the intracellular and extracellular fluids around to accommoda
 te curvature. To study this problem\, we develop new diffuse interface mod
 els for the dynamics of inextensible vesicles in a viscous fluid with stif
 f\, curvature-inducing molecules. A new feature of this work is the implem
 entation of the local inextensibility condition by using a local Lagrange 
 multiplier harmonically extended off the interface. To make the method eve
 n more robust\, we develop a local relaxation scheme that dynamically corr
 ects local stretching/compression errors thereby preventing their accumula
 tion. This is critical to accurately capturing hydrodynamic effects during
  endocytosis. By varying the membrane coverage of curvature-inducing molec
 ules\, we find that there is a cri tical (smallest) neck radius and a crit
 ical (fastest) budding time.\n\n
LOCATION:Seminar Room 1\, Newton Institute
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