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SUMMARY:From Cells to Seizures: Intrinsic Changes in Sodium Channel Expres
 sion  and Activity in Epilepsy - Professor  Manoj Patel\, University of Vi
 rginia Health Science Center\, USA.
DTSTART:20140710T100000Z
DTEND:20140710T110000Z
UID:TALK53348@talks.cam.ac.uk
CONTACT:Tony Jackson
DESCRIPTION:During the development of epilepsy a number of cellular events
  are initiated that ultimately lead to an increase in neuronal excitabilit
 y and the generation of seizures. The resurgent sodium current plays a maj
 or role in controlling neuronal excitability. Our studies demonstrate an i
 ncrease in resurgent sodium channel currents in medial entorhinal cortex (
 mEC) neurons recorded from a rat model of temporal lobe epilepsy  (TLE). I
 mportantly\, increases in the resurgent sodium current were detected at an
  early stage in the development of epilepsy\, and before the onset of spon
 taneous seizures. These studies suggest a critical role for the resurgent 
 current\, in part\, for establishing the increase in neuronal hyper-excita
 bility associated with epilepsy.
LOCATION:Seminar Room\, Department of Biochemistry Sanger Building\, Tenni
 s Court Road
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