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SUMMARY:Transcription regulation: from parts list to genomic network. - Ni
 cholas Luscombe
DTSTART:20061206T140000Z
DTEND:20061206T150000Z
UID:TALK5340@talks.cam.ac.uk
CONTACT:Ryan Prescott Adams
DESCRIPTION:The transcriptional regulatory system plays a central role in 
 directing gene expression changes in response to internal and external sti
 muli. In this talk\, first I wll present our work on transcription regulat
 ion in yeast\, ranging from large-scale experimental studies to computatio
 nal analyses of regulatory networks. I will introduce results from ChIP-ch
 ip experiments that identify genome-wide DNA-binding sites of transcriptio
 n factors\, particularly focusing on the cell cycle regulatory system. I w
 ill discuss how these observations fit in to an idea of a genomic regulato
 ry network\, and examine the effects of such networks on gene expression. 
 Later\, I will introduce preliminary results of our analysis of the transc
 riptional\nregulatory system in the human genome.\n\n\nVaquerizas JM\, Kum
 merfeld SK\, Dopazo J\, Teichmann SA & Luscombe NM. A functional census of
  human transcription factors. (submitted).\n\nLuscombe NM\, Babu MM\, Yu H
 \, Snyder M\, Teichmann SA & Gerstein M. Genomic analysis of regulatory ne
 twork dynamics. Nature 431\, 308-312.\n\nBabu MM*\, Luscombe NM*\, Aravind
  L\, Gerstein M & Teichmann SA. Structure and evolution of transcriptional
  regulatory networks. Current Opinions in Structural Biology\, 14\, 283-29
 1.\n\nYu H*\, Luscombe NM*\, Qian J & Gerstein M. Genome-wide analysis of 
 gene expression relationships in transcriptional regulatory networks. Tren
 d in Genetics\, 19\, 422-427.\n\nHorak C E\, Luscombe N M\, Qian J\, Berto
 ne P\, Piccirillo S\, Gerstein M & Snyder M. (2002). Complex transcription
 al circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes and
  Development \, 16\,\n3017-3033.\n\nFor further information about our grou
 p's work:\nhttp://www.ebi.ac.uk/luscombe
LOCATION:Ryle Seminar Room\, Cavendish Laboratory
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