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SUMMARY:Regulation of ageing by DAF-16/FOXO\, its cofactors\, and the chro
 matin landscape. - Dr Christian Riedel\, ERIBA\, Netherlands
DTSTART:20140925T120000Z
DTEND:20140925T130000Z
UID:TALK53723@talks.cam.ac.uk
CONTACT:Matthew Humphries
DESCRIPTION:Ageing and age-related diseases have become major determinants
  to human health and longevity. Fortunately\, ageing is extensively regula
 ted\, and thus the study of the underlying mechanisms may identify importa
 nt means to prevent or delay it.\n \nAgeing is controlled by several signa
 lling pathways that upon dire conditions induce stress responses\, which i
 ncrease the organism’s durability and longevity and thus its chances of 
 survival. Central player to many of these pathways is the transcription fa
 ctor DAF-16/FOXO\, which relays low insulin-like signalling (as a sign of 
 nutrient deprivation) but also other pro-longevity stimuli into the expres
 sion of stimulus-specific sets of stress response genes. Despite its impor
 tance\, much about the mechanisms by which DAF-16/FOXO’s specifies and r
 egulates its target genes has remained elusive.\n \nUsing the model system
  C. elegans\, we recently identified ~30 cofactors to DAF-16/FOXO\, all of
  which are essential for DAF-16/FOXO to fulfil its appropriate physiologic
 al roles. By focusing on one of them\, the chromatin remodeller SWI/SNF\, 
 we could show that DAF-16/FOXO employs chromatin remodelling at its target
  promoters as a means to induce transcription. We are now extending this w
 ork by exploring the mechanistic involvement of the remaining DAF-16/FOXO 
 cofactors as well as the chromatin landscape in ageing regulation.\n
LOCATION:The Babraham Institute - The Brian Heap Seminar Room
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