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SUMMARY:CVD Forum: Integrative Genomics of Gene Expression - Dr Kerrin Sma
 ll\, King's College London
DTSTART:20140910T140000Z
DTEND:20140910T150000Z
UID:TALK53883@talks.cam.ac.uk
CONTACT:38563
DESCRIPTION:Gene expression is an important cellular phenotype under both 
 genetic and environmental control.  Changes in gene expression appear to u
 nderlie the majority of genetic associations identified in genome-wide ass
 ociation studies of common disease. Studying the genetic regulation of gen
 e expression has thus been a fruitful strategy to unravelling the underlyi
 ng molecular mechanisms of common disease associated variants.  We have co
 llected deep ‘omic level data in the MuTHER study encompassing ~800 deep
 ly-phenotyped twins from the TwinsUK cohort\, including transcriptomics in
  three primary tissues (adipose\, skin\, whole blood) and one cell line (t
 ransformed lymphocytes).   Using this dataset we have identified and chara
 cterized regulatory variants (eQTLs) across the genome\, including a Type 
 2 Diabetes associated adipose-specific trans-regulatory network which I wi
 ll discuss.   Most common diseases result from both environmental and gene
 tic factors\, which can independently influence disease\, but may also int
 eract in complex ways.  We are thus in parallel exploring the relationship
  between gene expression and multiple environments (lifestyle factors and 
 biomedical measurements) with the end goal of identifying gene by environm
 ent interactions in the regulation of gene expression.  
LOCATION:New Seminar Rooms\, Strangeways Research Laboratory
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