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SUMMARY:COMT: from single nucleotide polymorphism to whole brain function.
  - Dr Elizabeth Tunbridge\, Department of Psychiatry\, University of Oxfor
 d
DTSTART:20141127T143000Z
DTEND:20141127T153000Z
UID:TALK54027@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Genome-wide association studies have identified single nucleot
 ide polymorphisms (SNPs) that confer increased risk for schizophrenia. How
 ever\, the biological mechanisms underlying these associations (and in som
 e cases the roles of the genes in which they located in brain function) ar
 e unknown.  My research aims to understand links between individual SNPs a
 nd whole brain function\; much of my work to date has focussed on a functi
 onal variant within the catechol-O-methyltransferase (COMT) gene.  I will 
 give a brief overview of the current understanding of the genetic architec
 ture of schizophrenia\, and will then focus on my research on COMT\, as an
  example of how we might start to move from individual risk SNPs to whole 
 brain function.
LOCATION:Part II Room\, Department of Genetics
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