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SUMMARY:Investigating heat shock signalling pathways in Arabidopsis thalia
 na and Saccharomyces cerevisiae - David Schoepfer\, Sainsbury Laboratory
DTSTART:20141204T130000Z
DTEND:20141204T133000Z
UID:TALK54578@talks.cam.ac.uk
CONTACT:Megan Cooper
DESCRIPTION:3rd year graduate seminarPlants are highly receptive to change
 s in ambient temperature\, with several hundred of genes being differentia
 lly regulated in Arabidopsis thaliana upon exposure to heat. The Wigge lab
 oratory has demonstrated that warm temperature responses in A. thaliana in
 volve a change in occupancy of the histone variant H2A.Z\, though the role
  of this chromatin alteration is currently unknown. Despite considerable e
 fforts to identify temperature sensors in plants\, the primary mechanism o
 f temperature perception remains to be discovered. To address these issues
 \, I am using a chemical genomics screen to identify proteins implicated i
 n temperature signalling in A. thaliana. In addition\, I am using a combin
 ation of mass spectrometry\, reverse genetics and chromatin immunoprecipit
 ation in the budding yeast Saccharomyces cerevisiae to identify potential 
 regulators of the transcriptional response to heat shock and to gain a bet
 ter understanding of the role of H2A.Z in regulating this response. As wel
 l as identifying key components of temperature signalling pathways\, this 
 project could potentially identify chemicals with useful agricultural appl
 ications\, such as thermal protection of plant reproduction.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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