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SUMMARY:Identifying microRNAs conditioning strong plant anti-aphid resista
 nce - Deusa Abreu\, Carr Lab
DTSTART:20141212T100000Z
DTEND:20141212T103000Z
UID:TALK54596@talks.cam.ac.uk
CONTACT:Megan Cooper
DESCRIPTION:1st year graduate seminar\n\n\nAphids transmit cucumber mosaic
  virus (CMV). In Arabidopsis thaliana infection by the Fny strain of CMV i
 nduces aphid feeding deterrence\; thought to promote virus transmission.  
 The CMV 2a protein triggers feeding deterrence but another CMV gene produc
 t\, the 2b RNA silencing suppressor protein\, induces stronger\, toxicity-
 based aphid resistance if expressed in transgenic plants.  The stronger 2b
 -induced aphid resistance results from disruption of microRNA (miRNA)-regu
 lated gene expression.  Since this stronger form of resistance might be us
 eful in plant protection\, I will identify specific miRNA(s) involved in i
 ts regulation.  I am using the LS CMV strain\, which does not induce resis
 tance to aphids in Arabidopsis\, as a carrier for ‘decoy’ sequences th
 at mimic miRNA targets and inhibit activity of specific Arabidopsis miRNAs
 .  I have generated a library of LS-CMV variants carrying mimic sequences 
 to identify miRNAs conditioning strong aphid resistance.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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