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SUMMARY:Computational Neuroscience Journal Club - Dylan Festa (University 
 of Cambridge)
DTSTART:20141118T160000Z
DTEND:20141118T170000Z
UID:TALK56201@talks.cam.ac.uk
CONTACT:Guillaume Hennequin
DESCRIPTION:Dylan Festa will cover:\n\nModeling the Dynamic Interaction of
  Hebbian and Homeostatic Plasticity\n\nT. Toyoizumi\, M. Kaneko\, M. P. St
 ryker and K. D. Miller\n\nNeuron\, 2014 (http://dx.doi.org/10.1016/j.neuro
 n.2014.09.036)\n\nHebbian and homeostatic plasticity together refine neura
 l circuitry\, but their interactions are unclear. In most existing models\
 , each form of plasticity directly modifies synaptic strength. Equilibrium
  is reached when the two are inducing equal and opposite changes. We show 
 that such models cannot reproduce ocular dominance plasticity (ODP) becaus
 e negative feedback from the slow homeostatic plasticity observed in ODP c
 annot stabilize the positive feedback of fast Hebbian plasticity. We propo
 se a model in which synaptic strength is the product of a synapse-specific
  Hebbian factor and a postsynaptic-cell-specific homeostatic factor\, with
  each factor separately arriving at a stable inactive state. This model ca
 ptures ODP dynamics and has plausible biophysical substrates. We confirm m
 odel predictions experimentally that plasticity is inactive at stable stat
 es and that synaptic strength overshoots during recovery from visual depri
 vation. These results highlight the importance of multiple regulatory path
 ways for interactions of plasticity mechanisms operating over separate tim
 escales.\n
LOCATION:Engineering Department\, Baker Building (5th floor)\, MIL meeting
  room
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