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SUMMARY:Evolution of the miRNA-mediated RNA silencing pathway: the plant  
 that wanted to be an animal - Adrian Valli (Baulcombe Lab)
DTSTART:20150212T130000Z
DTEND:20150212T133000Z
UID:TALK56593@talks.cam.ac.uk
CONTACT:Stephanie Swarbreck
DESCRIPTION:RNA silencing in the unicellular alga Chlamydomonas reinhardti
 i\, as in higher plants\, involves siRNAs and miRNAs that target transposo
 ns and mRNAs (Molnar et al. 2007). We have recently identified three indep
 endent mutants in the Dicer-like protein (DCL) 3 gene\, which were unable 
 to produce miRNAs and transposon-derived sRNAs. Analysis of sRNA and long 
 RNA in the dcl3 mutant and parental lines reveals that miRNA precursors in
  Chlamydomonas resemble those from animals rather than higher plants\, bec
 ause most of these precursors are hosted by either exons or introns of pro
 tein-coding RNAs. Interestingly\, as in animals\, mature miRNAs seem to be
  mainly controlling target expression at the translational level (our resu
 lts\, and others). Altogether\, these findings prompt a re-evaluation of t
 he hypothesis that miRNA systems evolved independently in plants and anima
 ls.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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