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SUMMARY:Remodeling of the erythroid proteome - Dan Finley\, Harvard
DTSTART:20150317T161500Z
DTEND:20150317T180000Z
UID:TALK57174@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Global remodeling of the proteome is an essential though littl
 e-understood aspect of terminal differentiation\, consisting of the progra
 mmed elimination of most generic constituents of the cell in parallel with
  abundant synthesis of a small number of new\, cell-type-specific proteins
  such as globin. Reticulocytes are a canonical example of a proteome in a 
 massive and rapid transition. However\, the mechanisms that drive rapid tu
 rnover of normally stable proteins in the erythroid lineage remain largely
  unknown. We will describe work implicating Ube2O in this process­–a ub
 iquitin-conjugating enzyme that is highly and selectively upregulated in t
 he erythroid lineage. Our findings indicate that successful terminal diffe
 rentiation can be driven by late-stage induction of a specific ubiquitinat
 ion program that is specific yet broad on scope. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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