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SUMMARY:MEDICAL  APPLICATIONS OF NANOSTRUCTURED SILICON : FROM THE CONCEPT
  TO THE CLINIC - Prof. Leigh Canham\, pSiMedica
DTSTART:20061020T143000Z
DTEND:20061020T153000Z
UID:TALK5724@talks.cam.ac.uk
CONTACT:spl37
DESCRIPTION:Nanostructuring materials can radically change their propertie
 s. Bulk or micromachined silicon structures are not biodegradable but meso
 porous silicon dissolves under physiological conditions.  I will describe 
 how two electrochemical etching techniques can be utilized to create kilog
 ramme quantities of mesoporous silicon microparticles. Low porosity radioa
 ctive forms of these are currently under clinical assessment for the targe
 ted treatment of primary liver cancer and pancreatic cancer. High porosity
  forms are undergoing pre-clinical R&D for controlled drug delivery. A lar
 ge fraction of active pharmaceutical ingredients now being discovered \, h
 ave issues with aqueous solubility\, and hence their use in therapy. Confi
 nement of such poorly soluble drugs in narrow enough pores can significant
 ly improve their bioavailability\, through a combined effect of nanostruct
 uring and solid state modification.\n\n \n\n
LOCATION: IRC in Superconductivity Seminar room
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