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SUMMARY:Single-cell dynamics of the proliferation-quiescence decision. - D
 r Sabrina Spencer\, Meyer Lab\, Stanford University Medical Center
DTSTART:20150423T133000Z
DTEND:20150423T143000Z
UID:TALK58072@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Tissue homeostasis in metazoans is regulated by transitions of
  cells between quiescence and proliferation. The hallmark of proliferating
  populations is progression through the cell cycle\, which is driven by Cy
 clin-dependent kinase (CDK) activity. I will discuss our recent developmen
 t of a live-cell sensor for CDK2 activity and the finding that proliferati
 ng cells bifurcate into two populations as they exit mitosis. Some cells i
 mmediately commit to the next cell cycle by building up CDK2 activity from
  an intermediate level\, while other cells lack CDK2 activity and enter a 
 transient state of quiescence. This bifurcation is directly controlled by 
 the CDK inhibitor p21 and is regulated by mitogens during a restriction wi
 ndow at the end of the previous cell cycle. We are currently exploring the
  role of cell stress in controlling this bifurcation in an attempt to unco
 ver the root cause of this striking divergence in cell fate.\n
LOCATION:Part II Room\, Department of Genetics
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