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SUMMARY:A forward genetic screen for Arabidopsis gene(s) that control meio
 tic recombination   - Divyashree Nageswaran\, 1st yr grad
DTSTART:20150501T090000Z
DTEND:20150501T093000Z
UID:TALK58769@talks.cam.ac.uk
CONTACT:Megan Cooper
DESCRIPTION:At present\, food production is inadequate to support the incr
 ease in global population. Introduction and implementation of modern appro
 aches in agriculture have the potential to increase crop yields through cl
 assical breeding that relies on natural variation. Meiotic crossovers betw
 een homologous chromosomes generate novel allelic combinations of benefici
 al traits. Studies on meiotic recombination in model species have led to t
 he identification of key genes that interfere crossover formation. For exa
 mple\, SPO11 is a key gene required for meiotic DSB formation that is cons
 erved across species. However\, it is likely that downstream genes that le
 ad to crossover remain to be identified. To isolate novel regulators of me
 iotic recombination in Arabidopsis\, I am conducting a forward genetic scr
 een using EMS-mutagenized 420 GR/++ fluorescent crossover reporter lines. 
 The aim is to isolate mutants that quantitatively alter crossover frequenc
 y and identify the mutated genes by genetic mapping. Understanding the fun
 ction of major factors in homologous recombination will be helpful to effe
 ctively manipulate and enhance crossovers thereby genetic variability duri
 ng crop improvement. In parallel\, I am designing and generating a novel f
 luorescent crossover reporter system that uses seed and pollen promoters s
 imultaneously. 
LOCATION:Sainsbury Laboratory
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