BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Beta oxidation in signalling and development. What plants can teac
 h us about yeast and animals - Alison Baker\, University of Leeds
DTSTART:20150618T120000Z
DTEND:20150618T130000Z
UID:TALK58906@talks.cam.ac.uk
CONTACT:38889
DESCRIPTION:Peroxisomes are arguably the most biochemically versatile of a
 ll eukaryotic organelles. Their metabolic functions vary between different
  organisms\, between different tissue types of the same organism\, and eve
 n between different developmental stages or in response to changed environ
 mental conditions. New functions for peroxisomes are still being discovere
 d and their importance is underscored by the severe phenotypes that can ar
 ise as a result of peroxisome dysfunction. The beta oxidation pathway is c
 entral to peroxisomal metabolism\, but the substrates processed are very d
 iverse\, reflecting the diversity of peroxisomes across species. Substrate
 s for beta oxidation enter peroxisomes via ABC transporters of the ABCD su
 b family and are  activated by specific acyl CoA  synthetases for further 
 metabolism. Humans have 3 peroxisomal ABCD family members\, which are half
  transporters that homodimerise and have distinct but partially overlappin
 g substrate specificity\; S.  cerevisiae has 2 half transporters that hete
 rodimerise  and plants have a single peroxisomal ABC transporter that  is 
 a fused heterodimer and which appears to be the single entry point  into p
 eroxisomes for a very wide variety of beta oxidation substrates. Our studi
 es suggest that the Arabidopsis peroxisomal ABC transporter AtABCD1 (COMAT
 OSE/PXA1/PED3) accepts acyl CoA substrates\, cleaves them before or during
  transport followed by reactivation by peroxisomal synthetases. We propose
  that this is a general mechanism to provide specificity to this class of 
 transporters and by which amphipathic compounds are moved across membranes
 .
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
END:VEVENT
END:VCALENDAR