BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Protein folding homeostasis in the endoplasmic reticulum: tuning a
  chaperone - David Ron\, University of Cambridge
DTSTART:20160129T161500Z
DTEND:20160129T171500Z
UID:TALK59075@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:A transcriptional and translational program that strives to ma
 tch the complement of chaperones in the endoplasmic reticulum (ER) to the 
 burden of unfolded proteins in the early secretory pathway (the Unfolded P
 rotein Response) has long been known to exist and its functional importanc
 e has been showcased by genetic and pharmacological manipulations. However
 \, theoretical considerations supported by experimental observations highl
 ight the latency inherent in this gene expression program and suggest the 
 potential importance of post-translational adaptations that operate on a s
 horter time scale. This seminar will review some recent observations perta
 ining to an ER-localized circuitry that tunes the activity of the compartm
 ent’s resident Hsp70 protein\, BiP\, to rapid fluctuations in unfolded p
 rotein load.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
END:VEVENT
END:VCALENDAR