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SUMMARY:Targeting Polycomb repression to the genome. - Dr Yuri Schwartz\, 
 Department of Molecular Biology\, Umea University\, Sweden 
DTSTART:20151022T130000Z
DTEND:20151022T140000Z
UID:TALK60346@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:As cells differentiate they acquire distinct gene expression p
 rofiles that cells “remember” when divide. Key to this memory are epig
 enetic mechanisms\, which control gene expression in a heritable way that 
 does not involve changes in the DNA sequence. Polycomb proteins comprise t
 he most appreciated regulatory system of this kind. Polycomb proteins act 
 in concert to repress multiple master regulatory genes and thereby prevent
  alternative gene expression programs from being executed within the same 
 cell. Polycomb repression of the master regulatory genes is specific and r
 obust. Paradoxically\, although the Polycomb proteins are active in all ce
 lls\, select target genes are spared from the repression in cells where th
 ey have to remain active. In addition to targeted repression\, Polycomb pr
 oteins survey the entire genome in a hit-and-run fashion to suppress perva
 sive transcription.\nIn this presentation I will focus on recent advances 
 in our understanding of how the Polycomb proteins target specific genes in
  a way that “senses” their transcriptional status. I will present our 
 view of the role of covalent histone modifications in the process and try 
 to connect the “targeted” and “hit-and-run” modes of Polycomb regu
 lation.
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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