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SUMMARY:Dr Yongliang Zhang: MKP5\, a novel regulator of  IRF3-type I IFNs\
 , critically modulates host-pathogen interaction in influenza and other RN
 A virus infections.   - Dr Yongliang Zhang\, National University of Singap
 ore
DTSTART:20151007T113000Z
DTEND:20151007T123000Z
UID:TALK60622@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:MAPK phosphatases (MKPs)\, also known as dual-specificity phos
 phatases (DUSPs)\, are known as important regulators in both innate and ad
 aptive immune responses\, mainly through their regulation of MAP kinase ac
 tivation. Previously\, we have shown that MKP5\, one of the MKP proteins\,
  is important for T helper cell activation and effector function by target
 ing JNK. \n\nOur recent investigation on this protein reveals a novel func
 tion of MKP5 in innate immune response to infection of RNA viruses includi
 ng influenza virus\, vesicular stomatitis virus and Sendai virus. The inte
 rferon regulatory factor 3 (IRF3) is known as the master regulator of type
  I interferons (IFNs) which are essential for host defence against viral i
 nfection. We found that the expression MKP5 induced by virus infection ina
 ctivates IRF3\, thereby inhibiting type I IFN response. \n\nTherefore\, th
 e induction of MKP5 expression could be part of the viral immune evasion s
 trategies to escape the type I IFN response. At the same time\, MKP5 could
  be a strategy of the host to regulate the intensity of antiviral immune r
 esponse to avoid uncontrolled immunopathology.   \n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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