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SUMMARY:Abdominal Aortic Aneurysm – just another form of atherosclerosis
 ? - Seamus Harrison\,  Consultant in vascular surgery
DTSTART:20151028T140000Z
DTEND:20151028T150000Z
UID:TALK61968@talks.cam.ac.uk
CONTACT:Narinder Bansal
DESCRIPTION:Abdominal Aortic Aneurysm (AAA) is characterized by chronic as
 ymptomatic dilatation of the aorta and aortic rupture\, an event with a mo
 rtality of approximately 75%. Unlike other forms of cardiovascular disease
 s\, there has been limited success in the use of pharmacological treatment
 s to alter the natural history of the disease but such a treatment would b
 e desirable as aortic repair comes with considerable morbidity\, mortality
  and expense. \n\nThe causal risk factors for AAA have proved elusive\, in
  part due a relative paucity of high quality prospective studies focusing 
 upon this phenotype. We have used GWAS and Mendelian Randomization to dete
 rmine potential causal pathways in AAA and study heterogeneity of genetic 
 association results across different cardiovascular diseases. This seminar
  will cover this work and our evaluation of inflammatory and lipid based p
 athways in AAA pathogenesis. It will also report the progress in the devel
 opment of large-scale population based studies to investigate the pathways
  involved in AAA progression and/or rupture.\n
LOCATION:Thomas Strangeways Room\, Strangeways Research Laboratory
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