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SUMMARY:Upside Down and Inside Out:  The Biomechanics of Cell Sheet Foldin
 g - Ray Goldstein\, DAMTP\, Cambridge University
DTSTART:20151111T141500Z
DTEND:20151111T151500Z
UID:TALK62326@talks.cam.ac.uk
CONTACT:Lucy Colwell
DESCRIPTION:Deformations of cell sheets are ubiquitous in early animal dev
 elopment\, often arising from a complex and poorly understood interplay of
  cell shape changes\, division\, and migration. I will describe our work o
 n perhaps the simplest example of cell sheet folding: the “inversion” 
 process of the algal genus _Volvox_\, during which spherical embryos turn 
 themselves inside out through a process hypothesized to arise from cell sh
 ape changes alone.  We have used light sheet microscopy to obtain the firs
 t three-dimensional visualizations of inversion _in vivo_\, and developed 
 the first theory of this process\, in which cell shape changes appear as l
 ocal variations of intrinsic curvature\, contraction and stretching of an 
 elastic shell. Our results support a scenario in which these active proces
 ses function in a defined spatiotemporal manner to enable inversion.\n
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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